Class: Prostaglandins, Endocrine, Abortifacient
A medication called Hemabate (carboprost tromethamine) Sterile Solution contains prostaglandin, a hormone-like molecule found in the human body. It is used to induce abortion by causing uterine contractions and to treat severe postpartum bleeding (postpartum hemorrhage). Hemabate is often given between weeks 13 and 20 of pregnancy, though it may also be used at additional stages if necessary for medically necessary reasons. Hemabate is frequently advised when an alternative type of abortion hasn’t completely removed the uterine contents or when a pregnancy issue requires an early delivery because the fetus’ viability is in question.
Forms and Strengths of Dosage:
The recommended dosage for the injectable solution is 250 mcg/mL.
The following dosage schedule is suggested for abortion:
Start with an intramuscular (IM) injection of 250 micrograms.
Subsequent Doses: If necessary, repeat in 1.5 to 3.5 hours.
Initial testing dose of 100 mcg intramuscularly (IM) is available as an option.
If the initial 250 mcg dose does not have the desired effect, the dose can be increased to 500 mcg intramuscularly (IM).
Never provide more than 1200 mcg in a 24-hour period, and don’t give it for more than 2 days straight.
Persistent Uterine Bleeding After Delivery:
Following is a suggested dosage schedule for persistent bleeding after delivery:
First-Time Dose: 250 mcg Intramuscularly.
Subsequent Doses: Administer every 15-90 minutes as needed.
Not more than 8 doses, or a total of 2000 mcg, should be given.
This is intended merely as a resource, and any recommendations or advice given here should only be implemented after consulting with a trained medical expert. Dosing and administration of medications should be adjusted according to each patient’s unique medical condition and requirements.
Common adverse reactions to the drug are listed here, but their incidence is not specified.
The most typical consequence is an increase in the contractility of smooth muscle.
About a third of people experience nausea.
About two-thirds of people experience nausea and vomiting.
Approximately two-thirds of individuals experience diarrhea.
- An episode of epistaxis.
- Disturbances in sleep.
- Excessive heat in the body, often known as hyperthermia.
- Turning red from flushing.
- Pain in the chest.
- High blood pressure (hypertension).
- Syncope, or passing out.
- A racing heartbeat (palpitations).
- Rapid heartbeats, or tachycardia.
- discomfort in the chest.
- Dystonia, or involuntary muscle contractions leading to improper movement or posture.
Please note that these side effects may occur less frequently or more severely in some people than in others, and that it is critical to speak with a medical practitioner to fully understand the risks and benefits of this medicine.
|Caution, Black Box:
This drug has strong oxytocic properties. It is crucial that the prescribed dosage be followed exactly. Only medical professionals in an emergency room or operating room with immediate medical and surgical care capabilities should administer this product.
The following conditions are not appropriate for use of this medication:
Drug intolerance or sensitivity.
Syndrome of acute pelvic inflammation.
A current medical condition affecting the heart, lungs, kidneys, or liver.
When it comes to the following, use caution:
People who have had glaucoma or high IOP in the past.
Asthmatics, hypertensives, hypotensives, and cardiology patients.
Carboprost’s effect on hypothalamic thermoregulation may explain why some patients experience transient fever while being treated.
Patients with conditions including anemia, jaundice, renal impairment, hepatic impairment, diabetes, and epilepsy need to be treated with extra caution.
Pretreatment or concomitant use of antiemetic and antidiarrheal medicines may be necessary to reduce gastrointestinal adverse effects.
This drug should not be given intravenously (IV).
Keep in mind that prostaglandins have been linked to extremely rare instances of cardiovascular failure.
When any of the warnings listed above relate to a patient’s health situation, it is crucial to adhere to these contraindications and proceed with caution. If you need specific advice or recommendations about this drug, always check in with your doctor first.
Information Regarding Pregnancy and Breastfeeding:
Category C for Pregnancy
Not much is known about the excretion process in breast milk.
Classifications of Pregnancy:
Type A: Acceptable by the majority of people. There is no proof that the fetus was harmed in controlled research including pregnant women.
Class B: Possibly suitable for acceptance. Either no danger was found in animal research but no human studies were available, or very low hazards were found in animal studies but were not replicated in subsequent human investigations.
Use with caution; Category C warning; acceptable if benefits exceed hazards. While there may be a danger, human studies have either not been done or are lacking.
Only used in life-threatening crises where no other option is available. Category D. There is solid proof of prenatal danger in humans.
Do not use if you are pregnant; X-category products. There are less dangerous options that can achieve the same goals.
Pregnancy-related data are presently unavailable; hence, NA (Not Available) is displayed.
The categories for use during pregnancy and lactation help determine whether or not the drug is safe for the mother and baby. It’s important to get a professional medical opinion on the dangers and advantages in your particular case.
The Workings of the Drug:
This medicine works by causing smooth muscle contractions, which then causes the placenta and fetus to be thrown out. It’s used to induce abortions between the ages of 13 and 20 weeks’ gestation. The release of norepinephrine is also inhibited, and its effects at neuroeffector sites are modified.
About 20-30 minutes after delivery is when plasma concentrations are highest.
The normal concentration in blood plasma is between 1.1 and 1.6 ng/mL.
The half-life of this elimination process is roughly 3 hours.
Weak binding to plasma proteins, if any.
The majority of medication removal is carried out by the kidneys, with the majority of the drug ending up in the urine.
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