Chlorthalidone oral: Uses, Side Effects, Dose, How to Use, Interaction, Precaution

Chlorthalidone oral: Uses, Side Effects, Dose, How to Use, Interaction, Precaution


Chlorthalidone treats hypertension alone or with additional drugs. Having high blood pressure puts stress on the cardiovascular system. Stroke, heart failure, and renal failure are all possible outcomes of untreated hypertension that has progressed over time. The danger of a heart attack is amplified by hypertension. Controlling high blood pressure lessens the likelihood of developing secondary health issues.

Congestive heart failure, severe liver illness (cirrhosis), kidney disease, or hormonal or steroid treatment can cause edema, which chlorthalidone treats.

The diuretic chlorthalidone is called a “water pill.” Urination increases water loss, lowering blood pressure.

This drug requires a doctor’s prescription.

This tablet-based product is only available under medical supervision.

Before Use

This medication’s hazards must be weighed against its advantages. Together with your doctor, make this decision. The following should be considered:

If you have had any unexpected or allergic responses to this prescription or other drugs, inform your doctor. List any additional allergies, such as food, colors, preservatives, or animals. Read non-prescription product labels and packaging for ingredients.

No studies have been completed on the role of age in the effects of chlorthalidone in children. The safety and efficacy of this medicine for children have not been demonstrated.

No specific issues have been identified that would limit the use of chlorthalidone in the elderly, according to current studies. Age-related renal disease is more common in elderly people, hence chlorthalidone dosage may need to be adjusted.

There is insufficient research on the potential dangers to infants while using this drug during nursing. Before using this medicine while breastfeeding, weigh the risks and benefits.

Drug Interactions:

 It is not recommended to use certain drugs with this medicine, although a healthcare provider may decide otherwise. If both drugs are prescribed, the doctor may change dosage or frequency. Explain to your doctor everything you’re taking. The following interactions may be significant but not all:

  • Acarbose
  • Aceclofenac
  • Acemetacin
  • Acetyldigoxin
  • Albiglutide
  • Albuterol Alogliptin
  • Amtolmetin Guacil: Arsenic Trioxide
  • Aspirin
  • Bepridil
  • Bromfenac
  • Bromocriptine
  • Bufexamac
  • Buprenorphine
  • Canagliflozin
  • Celecoxib
  • Chlorpropamide
  • Choline Salicylate
  • Codeine – Clonixin
  • Dapagliflozin
  • Deslanoside
  • Desmopressin
  • Dexibuprofen
  • Dexketoprofen
  • Diclofenac
  • Diflunisal Digitalis
  • Digitoxin
  • Digoxin
  • Dipyrone dofetilide

In conclusion, consider allergic reactions, age-appropriate use, nursing, and drug interactions before taking this medication. For an informed use decision, explore these factors with your doctor.

How to use

To maximize your treatment, use this medication as prescribed. Do not exceed your doctor’s dosage or duration. To aid in recall, take your medication at the same time each day.

This drug and weight control and diet adjustments, especially those high in sodium or potassium, may treat high blood pressure. Your doctor will advise you on which is most crucial. Consult your doctor before modifying your diet.

Many high blood pressure patients have no symptoms. Indeed, many may feel normal. If you’re feeling fine, you still need to take your medication as prescribed and follow your medical visits.

The medicine manages high blood pressure but does not cure it. If you want to lower and maintain your blood pressure, take it as prescribed. High blood pressure medication may be lifelong. High blood pressure can cause heart failure, blood vessel damage, stroke, and renal disease if untreated.

This medication is taken with food in the morning.

Side Effects

Consult your doctor immediately if any negative effects occur:

  • Pain in the abdomen
  • Black, tarry stools
  • Gums bleeding
  • Skin blistering, peeling, or loosening
  • Bloating
  • Bloody stools or urine
  • Vision blurred
  • Chest pain
  • Chills
  • Stools with clay
  • Cold sweats
  • Confusion
  • Cough/hiness
  • Coughing up blood
  • Dark urine
  • Diarrhea
  • Trouble pooping
  • Lightheadedness or dizziness after standing up from a laying or sitting position
  • Mouth dry
  • Fast heartbeat
  • Fever
  • Flushed, dry skin
  • Fruity breath odor
  • General fatigue or weakness
  • Headache

Some adverse effects may occur, but any of the above symptoms require prompt medical attention for evaluation and treatment.


Patients will receive varying doses of this drug. Follow your doctor’s or label’s instructions. Only the typical doses of this drug are listed. Only your doctor should tell you to adjust your dosage.

The strength of the drug determines the dosage. The medical problem you’re treating determines the number of pills you take daily, the duration between doses, and how long you take the medicine.

For oral tablets, for fluid retention (edema) in adults, start with 50-100 mg daily or 100 mg every other day. If needed, your doctor may change your dose.

Children—Doctors must determine use and dose.

High blood pressure:

Adults should start with 25 mg of chlorthalidone daily. If needed, your doctor may change your dose.

Thalitone®: 15 mg daily initially. After 2 weeks, you can increase to 25 mg daily as needed.

Children—Doctors must determine use and dose.

Missed dosage

Don’t wait to take this medication if you forget to. If your next dose is approaching, you should not take the missing one. Please don’t take twice the prescribed dose.


The medication should be stored in a dark, cool place away from sources of heat or moisture. Keep from freezing. Secure from youngsters.

Do not store expired or unnecessary medication.

Ask your doctor how to dispose of unused medicine.

Chlorthalidone tablets 25 mg, 12.5 mg uses, Side Effects, Dose, Pharmacology

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