Dinoprostone (Vaginal route): Uses, Side Effects, Dose, Interaction,

Dinoprostone (virginal Route): Uses, Side Effects, Dose, Interaction, Precaution, Warnings


American Brands: Cervidil, Prepidil, E2 Prostin


Dinoprostone works by stimulating uterine contractions and cervical thinning/dilation (opening), thereby simulating the effects of childbirth. Your doctor may find alternative applications for dinoprostone as well. Only a doctor or other trained medical practitioner should give you this medication.

Different Dosage Options:


Prolonged-Release Insert

To Prevent Misuse:

You and your doctor will weigh the benefits of using this drug against its potential negative effects before making a final choice. The following considerations are 

Relevant to this medication:

Please Ask your doctor if you have ever had any adverse response to this or any other medicine. Any other allergies you may have, whether to foods, dyes, preservatives, animals, etc., should be mentioned as well. Always check the label or box for a list of ingredients before using any over-the-counter medication.

No adequate studies in women have been done to determine the safety of this drug for nursing infants. Before using any drug while nursing, it is important to Compare the benefits and the risks.

Some medications should never be used together due to the risk of an interaction, whereas in other cases, two medications may be used together despite the possibility of an interaction. Your physician might have to alter the dosage or take additional safety measures in such circumstances. Your doctor should know if you are taking any of the following medications (chosen for potential significance but not necessarily all-inclusive) while getting this medication:


Other Interactions:

 It is important to remember that certain medications should not be taken with, or within two hours of, certain foods. Some drugs can interact negatively with alcohol and tobacco usage. Before combining any drug with anything, including food, alcohol, or tobacco, talk to your doctor.

The existence of additional medical issues may affect how this drug is used. The following conditions:

  • Preexisting anemia
  • asthma or a history of asthma, particularly asthma in childhood
  • Poor lung health
  • Glaucoma
  • Having a history of heart or blood vessel disease
  • A current or past diagnosis of hypotension
  • A diagnosis or history of kidney illness
  • A diagnosis or history of liver illness
  • Pregnancy or delivery history fraught with difficulty
  • Having had a hysterectomy or a history of having one
  • Hemorrhaging in the genital area


Use Correctly:

If you take dinoprostone, you should rest comfortably in bed between ten minutes and two hours. afterward. Reclining for what amount of time is dependent on the medication and its delivery method.


various patients will require various amounts of this medication. To use, just do as directed by your doctor or the label. The dosage is based on the medicine’s potency, the daily dosages, intervals between medications, and the length of time the medicine is used to treat the ailment.

Dinoprostone 0.5 mg (one application) is placed into the cervix canal to thin the cervix and dilate it in preparation for labor in adults and teenagers. Ten to thirty minutes following application, the patient should continue to lie supine.

Adults and adolescents will apply 1 milligram (mg) (one applicatorful) of dinoprostone gel into the vagina to stimulate uterine contractions for childbirth. They need to lie flat for at least half an hour after application. Six hours following the initial dose, it’s possible that another 1–2 mg will be required.

For the vaginal dose form (suppositories), 20 milligrams (mg) (one suppository) is put into the vagina every three to five hours as needed to produce uterine contractions for pregnancy termination in adults and teenagers. After the catheter has been inserted, the patient should lie flat for at least ten minutes.

Adults and adolescents will insert 10 milligrams (mg) (one system) into the vagina to thin the cervix and dilate it in preparation for labor. After the catheter has been inserted, the patient should Spend at least two hours lying flat.

Side effects

A medicine may have undesirable consequences even when it is necessary for its intended uses. Even while not all of these adverse effects are certain to happen, if they do, medical intervention may be required.      

If you develop any of the following adverse effects, call your doctor right away:

  • Less frequent or uncommon:
  • A quick or slow heartbeat
  • Hives
  • higher uterine pain
  • blotchy, cold, and pale skin on the arms or legs
  • chest pain or discomfort
  • breathing difficulty
  • face, inside nose, and eyelid swelling
  • chest constriction
  • breathing problems
  • pulse in the arms or legs is weak or nonexistent.
  • Wheezing

There could be some adverse effects, but they usually don’t need emergency medical treatment. These negative effects subside as your body adapts to the medication. may go away during the course of treatment. Your healthcare provider might also offer advice on how to avoid or lessen specific side effects. If any of the following side effects linger, become troublesome, or you have any questions about them, speak with your healthcare provider:

  • More typical
  • stomach or abdominal cramps
  • Diarrhea
  • Fever
  • Nausea
  • Vomiting

Less frequent or uncommon:

  • shivering or chills
  • Constipation
  • Flushing
  • Headache
  • vulva-related vaginal swelling
  • tender or barely bloated stomach or abdomen

Dinoprostone tablets uses, Side Effects, Dosage and more Hindi/urdu 👇

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