Mifepristone (prescription only)
Brand & other name: Mifeprex; Korlym, ru486;
Class: Antiprogestins; Cortisol Receptor Blockers
Mifepristone, often known as RU 486, is a medication that is administered to end pregnancies in the first few weeks of pregnancy (70 days following the first day of the last menstrual period). Naturally occurring chemical called progesterone, which is necessary for maintaining pregnancy, is what mifepristone does. It is typically given along with another drug called misoprostol. It is crucial to understand that Mifepristone should not be used in cases of extremely uncommon abnormal pregnancies that take place outside the uterus, or ectopic pregnancy. In these situations, Mifepristone won’t cause the pregnancy to end, but it could cause an ectopic pregnancy to burst, which could cause a serious hemorrhage.
Mifepristone oral how to use
Before beginning therapy with mifepristone, start by reading the medication guide that was given to you by your doctor. Keep this manual on hand in case you need it in the future. Read and sign the Patient Agreement document that was sent to you by your doctor as well. Get professional guidance from a doctor or pharmacist.
It takes at least two trips to your doctor’s office to finish your therapy and have any necessary tests performed. Only medical experts who are directly overseeing the administration of this medicine. Make sure you are aware of the right people to contact and what to do in case of a medical emergency.
In order to ensure that your pregnancy is inside the first ten weeks and is inside the uterus, confirming it is not an ectopic pregnancy, your doctor may advise having an ultrasound examination.
In accordance with your doctor’s recommendations, take one dose of mifepristone orally. Your doctor will tell you to wait between 24 and 48 hours after taking Mifepristone before taking Misoprostol orally in a single dose. It’s crucial to follow this rule since if you Misoprostol should be used within 24 hours of Mifepristone or later than 48 hours following its administration, the medications’ efficiency may be jeopardized. Listen carefully to what your medical professional has to say. It is important to understand that significant vaginal bleeding does not always signify the end of the pregnancy.
While taking this medication, avoid drinking grapefruit or grapefruit juice unless specifically told by your doctor or pharmacist that it is okay to do so. The likelihood of experiencing negative effects when taking this medication can increase if grapefruit is consumed. For further information, consult your healthcare provider or pharmacist.
Even if you are not experiencing any difficulties, it is crucial that you arrange a follow-up appointment within a window of 7 to 14 days after the administration of Mifepristone.
Surgical intervention can be required if the pregnancy continues or if serious medical problems develop. There is a chance of congenital birth abnormalities in situations where the treatment is inadequate and the pregnancy ends in birth.
Mifepristone oral side effects
Potential adverse effects include weakness, dizziness, nausea, vomiting, and diarrhea. Seek medical attention if any of these symptoms continue to immediate medical assistance. last more than 24 hours after taking the second medication, misoprostol, as they may be signs of a serious medical problem.
During this treatment, it’s expected that you’ll experience bleeding and cramping. Generally speaking, these symptoms show whether the medications are working. However, it is possible to have cramps and bleeding while still carrying a child. Attending all of your doctor’s scheduled follow-up appointments on time is essential. Your doctor may occasionally prescribe additional medication to treat nausea and cramps, especially in the first 24 hours after taking the second drug, misoprostol. Talk to your healthcare provider or pharmacist immediately. When any of these signs and symptoms persist for longer than usual or get worse.
Spotting and bleeding could last up to 30 days and be much heavier than usual monthly bleeding. Such severe bleeding may, in rare cases, require surgical intervention. Seek emergency medical assistance if you experience excessive bleeding that soaks through two full-size, thick sanitary pads in a single hour or if you have concerns about heavy bleeding.
Remember that your physician has suggested this medicine because they believe the advantages outweigh the possible negative effects. It is important to recognize that many people taking There are no major negative reactions to this medication.
Immediately seeking medical attention is a need. if you’re experiencing major adverse effects. The commencement of a temperature that registers at 100.4 degrees Fahrenheit (38 degrees Celsius) or higher, episodes of fainting, a rapid heartbeat, and the development of stomach or abdominal pain or soreness are among these serious adverse effects.
An exceedingly severe allergic reaction to this medicine is conceivable, notwithstanding its great rarity If you observe any of the following signs of a severe allergic reaction, including the emergence of a rash, swelling, or itching Bruising (particularly of the face, tongue, or throat), Disorientation, Severe or breathing difficulties, Getting checked out by a doctor immediately is a must.
Please be aware that the complete range of potential adverse effects is not covered in this compilation. Kindly notify your doctor or pharmacist if you notice any additional effects that aren’t covered here.
Mifepristone oral warnings
Rarely, the end of a pregnancy can result in serious medical issues, some of which may be life-threatening, like infections and severe hemorrhaging. It is vitally important to go through the Medication Guide, sign the Patient Agreement, and consult with your doctor if you have any questions. To get this drug in the United States, one must fully comprehend, give consent to, and strictly abide by the requirements set forth in the Mifepristone REMS Program. It is highly advised for people who live in Canada or other nations to speak with their doctor and pharmacist to learn about the laws that apply to your particular location.
In the event of an emergency, such as the commencement of serious bleeding or the appearance of an infection, your doctor is responsible for providing you with exact instructions outlining who to contact and what to do. It is crucial that you show the Medication Guide to any healthcare providers you consult with or visit in case you feel the need to go to the emergency department or terminate the pregnancy.
If you experience symptoms like severe abdominal pain, unconsciousness, an accelerated heart rate, or a fever that lasts longer than four hours, you should seek medical attention right away because these symptoms could indicate a very serious infection even if you don’t have a fever. In a similar vein, regardless of whether you have a fever, you must promptly seek medical attention if you experience abdominal discomfort or a feeling of illness accompanied by symptoms like nausea, vomiting, diarrhea, or weakness that lasts longer misoprostol, the second pill, more than 24 hours later. Additionally, continued heavy bleeding calls for immediate medical attention because it may be an indication that the pregnancy has not been effectively terminated or that other serious medical problems exist. In such cases, surgical procedures or alternative medical care may be necessary. For more details, please check review the Side Effects section.
Mifepristone oral precaution
It is crucial to tell your doctor about any allergies before starting Mifepristone therapy. All known allergies are covered, including those to mifepristone itself, misoprostol, other progestins like norethindrone, and other progestins. This drug might include inactive components that could cause allergic reactions or other negative side effects. Consult your pharmacist for more thorough information.
Inform your doctor or pharmacist about your medical history prior to starting this treatment, paying close attention to the following: the presence of an undiagnosed abdominal growth called an adnexal mass, any problems with the adrenal glands, any bleeding disorders, certain hereditary blood disorders called porphyrias, and a low blood count (anemia).
Before beginning therapy with mifepristone, an intrauterine device (IUD) must be removed if you are currently using one.
Only if you have reliable access to emergency medical assistance should you experience a serious medical problem should you administer this medication.
Mifepristone has the capacity to cause lightheadedness. This drowsiness could be exacerbated by the use of alcohol or cannabis. It is advised to delay engaging in alertness-requiring tasks, such operating machinery or driving, until you can do so safely.
Mifepristone normally causes fetal death, while there is a small chance that birth abnormalities could occur in rare cases where a pregnancy continues after treatment.
It’s vital to remember that further pregnancies could happen after taking this drug but before your usual menstrual cycle resumes. As soon as this treatment is properly finished, birth control methods can be put in place. It is advised to consult your healthcare practitioner for more advice on this subject.
Breast milk is excreted by this medicine. Lactating women are recommended to speak with their healthcare providers about whether they should temporarily stop breastfeeding after receiving mifepristone because the effects of this medication on infants are still unknown.
Mifepristone oral interaction
Drug interactions may alter how well your prescriptions work or increase your chance of experiencing serious adverse effects. Not all possible medication interactions are included in this document. Maintaining a list of all the goods you are now utilizing is advised. Both prescribed and nonprescription drugs should be included as well as herbal supplements. Any medication should not be changed, stopped, or adjusted in dosage without your doctor’s express consent.
This medication has the potential to interact with specific items. These include prolonged corticosteroid therapy, such as prednisone, and other medications that can cause bleeding or bruising, such as NSAIDs like ibuprofen and naproxen, antiplatelet medications like clopidogrel, and anticoagulants like warfarin and dabigatran.
Aspirin use while taking this drug may increase the risk of bleeding. However, if your doctor has recommended low-dose aspirin (usually 81–162 milligrams per day) to prevent heart attacks or strokes, you should keep taking it unless specifically instructed differently by your healthcare practitioner. For more information, visit your doctor or pharmacist.
Numerous other drugs may impact how quickly your body gets rid of mifepristone, which may affect how effective it is. These include rifamycins like rifabutin, St. John’s wort, and numerous antiepileptic medications like carbamazepine and phenytoin, as well as azole antifungals like itraconazole and dexamethasone, macrolide antibiotics like erythromycin, and rifamycins like rifabutin.
Mifepristone, on the other hand, has the ability to slow down the clearance of other drugs from your body, which may affect how well they work. Cyclosporine, ergot alkaloids including dihydroergotamine and ergotamine, fentanyl, pimozide, quinidine, several statin medications like fluvastatin, lovastatin, and simvastatin, sirolimus, tacrolimus, warfarin, and numerous more medications are examples of those that may be impacted.
Medical exams could be necessary while taking medicine. Schedule appointments.
“Consult your doctor for more information.”
Follow your doctor’s instructions regarding dose. If you are late for an appointment, call them.
Keep items at room temperature and away from moisture and light. Keep the kids and the animals away. Never flush anything down the toilet. Once expired, dispose of properly. Speak with your pharmacist.